5 resultados para HIV, primary resistance to antirretrovirales, virologic faulier, secondary resistance

em Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco


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[Es] Esta aportación sintetiza el estudio que están desarrollando profesores del Área de Didáctica y Organización escolar de la UPV y de la UAB (2005-06). Su contenido aborda las relaciones entre los estadios de desarrollo organizativo y curricular y los resultados escolares. Los primeros datos sugieren que hay una mayor cohesión y coherencia en los centros pequeños, de titularidad pública y de un solo modelo lingüístico. Curiosamente, esta aparente identidad común se apoya más en la estructura participativa y en los sistemas de aprendizaje organizacional y no tanto en la cultura institucional y la cultura colaborativa. Estas últimas dependen más del tamaño del centro y del modelo lingüístico que de la titularidad. Llama la atención que el liderazgo transformacional se vincula más a la titularidad pública y a los centros de secundaria, no relacionándose significativamente con el tamaño del centro, el modelo lingüístico o los años vinculados al ejercicio de cargos.

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[eus] Gradu Amaierako Lan honek Haur Hezkuntzako etapan familia aniztasunari ematen zaion trataera aztertzea du helburu. Horretarako Bilboko Elizbarrutiko ikastetxe zehatz batean kasu ikerketa bat egitea erabaki da. Azterketaren ardatza ikastetxearen izaera konfesionala familia eredu berrien aniztasuna lantzeko zenbateraino traba izan litekeen frogatzea izan da. Ikerketarako erabilitako metodologia kualitatiboa izan da, eztabaida taldea, elkarrizketa sakonak, behaketak eta edukien analisien bidezko teknikak nagusiak izanik. Teknika horien bitartez lortutako informazioaren inguruan zenbait ondorio atera dira eta, azkenik, horiek guztiak kontuan harturik hobekuntzarako proposamena planteatu da.

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[EN]This research had as primary objective to model different types of problems using linear programming and apply different methods so as to find an adequate solution to them. To achieve this objective, a linear programming problem and its dual were studied and compared. For that, linear programming techniques were provided and an introduction of the duality theory was given, analyzing the dual problem and the duality theorems. Then, a general economic interpretation was given and different optimal dual variables like shadow prices were studied through the next practical case: An aesthetic surgery hospital wanted to organize its monthly waiting list of four types of surgeries to maximize its daily income. To solve this practical case, we modelled the linear programming problem following the relationships between the primal problem and its dual. Additionally, we solved the dual problem graphically, and then we found the optimal solution of the practical case posed through its dual, following the different theorems of the duality theory. Moreover, how Complementary Slackness can help to solve linear programming problems was studied. To facilitate the solution Solver application of Excel and Win QSB programme were used.

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Background: Human endogenous retroviruses (HERVs) are repetitive sequences derived from ancestral germ-line infections by exogenous retroviruses and different HERV families have been integrated in the genome. HERV-Fc1 in chromosome X has been previously associated with multiple sclerosis (MS) in Northern European populations. Additionally, HERV-Fc1 RNA levels of expression have been found increased in plasma of MS patients with active disease. Considering the North-South latitude gradient in MS prevalence, we aimed to evaluate the role of HERV-Fc1on MS risk in three independent Spanish cohorts. Methods: A single nucleotide polymorphism near HERV-Fc1, rs391745, was genotyped by Taqman chemistry in a total of 2473 MS patients and 3031 ethnically matched controls, consecutively recruited from: Northern (569 patients and 980 controls), Central (883 patients and 692 controls) and Southern (1021 patients and 1359 controls) Spain. Our results were pooled in a meta-analysis with previously published data. Results: Significant associations of the HERV-Fc1 polymorphism with MS were observed in two Spanish cohorts and the combined meta-analysis with previous data yielded a significant association [rs391745 C-allele carriers: p(M-H) = 0.0005; ORM-H (95% CI) = 1.27 (1.11-1.45)]. Concordantly to previous findings, when the analysis was restricted to relapsing remitting and secondary progressive MS samples, a slight enhancement in the strength of the association was observed [p(M-H) = 0.0003, ORM-H (95% CI) = 1.32 (1.14-1.53)]. Conclusion: Association of the HERV-Fc1 polymorphism rs391745 with bout-onset MS susceptibility was confirmed in Southern European cohorts.

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[eus] Gaur egun, aditu desberdinek diotenez, Lehen Hezkuntzan konpetentzia zientifikoa garatzeko zailtasunak daude . Egoera hobetzeko, kultura zientifikoan murgiltzeko aukera, eta argumentazio gaitasuna garatzeko aukera eskaini behar zaie ikasleei. Esku-hartze honetan, eztabaida soziozientifikoen bidez, argumentazio gaitasuna lantzen da, sendagaien eraginkortasuna eta efektu sekundarioen arteko harremana eztabaidagai izanik. Esku-hartzea burutzean, ikusi ahal izan da adin txikiko ikasleak, aukera eskaintzen zaienean, argumentu justifikatuak emateko gai izan direla konpetentzia zientifikoa lortzeko bidea eraikiz. Aldi berean, sendagaien eraginkortasunaren eta efektu sekundarioen arteko harremanaz ohartu dira.